The Seasiders were dominant from the first whistle and striker Gary Taylor-Fletcher was left free to tuck home Marlon Harewood's 16th-minute cross.
After 37 minutes a mistake from Latics skipper Chris Kirkland gifted Harewood Blackpool's second before the burly striker added another two minutes before the break.
Alex Baptiste got a fourth 15 minutes from time to round off a fantastic day for Ian Holloway's men in their first top-flight match since 1971.